Data preprocessing and analysis of bacterial RNA fragments for diagnostic purposes

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has title::Data preprocessing and analysis of bacterial RNA fragments for diagnostic purposes
status: finished
Master: project within::Bioinformatics
Student name: student name::Michiel Vegt
Dates
Start start date:=2011/04/11
End end date:=2011/08/11
Supervision
Supervisor: Sanne Abeln
Second reader: has second reader::Thomas Binsl
Company: has company::Crosslinks
Thesis: has thesis::Media:Thesis.pdf
Poster: has poster::Media:Media:Posternaam.pdf

Signature supervisor



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Abstract

A new method has been developed to diagnose bacteria targeting species-specific regions in the bacterial DNA. The main aim of this project is to preprocess data by applying several de-noising algorithms. This project will be performed at Crosslinks. Below you will find some more information about this company.


Crosslinks is a high-tech Bioinformatics company founded in 2005 as spin-off from the department of Bioinformatics at the Erasmus Medical Center in Rotterdam. Crosslinks is focused on delivering validated (CE, FDA) computational solutions for bedside diagnostics and prognostic decision-making.

Crosslinks is an experienced partner for bioinformatics data analysis, software and database services, advanced visual informatics, product solutions and technology consultation for life science companies, biomedical research and other markets. In addition, Crosslinks is the official partner of Tibco and provides Spotfire licensing agreements and implementation knowledge to academic researchers in the Netherlands and the rest of Europe.

Crosslinks is producing a robust diagnostic analysis platform to support Skyline Diagnostics in their efforts to deliver microarray-based diagnoses of Acute Myeloid Leukemia (AML). The platform provides remote diagnostic services to laboratories located around the world. This allows a fast and accurate identification of Leukemia subtypes and enables to employ the most effective subtype-specific treatments as quickly as possible.

Another product of Crosslinks is V-Scope, which provides 3-D medical image rendering and medical virtual reality visualization. This innovative product enables researchers and clinicians to analyze and manipulate their image datasets in a more sophisticated way. V-Scope promotes the development of a new anatomical understanding and due to its performance assists by complex multidisciplinary diagnostics.

Finally, Crosslinks is participating in multiple EU projects such as MoodInFlame, HiPerDART and RATstream to increase its network as well as its product and knowledge portfolio.