Difference between revisions of "Simulation of optimal stress responses of microorganisms using whole-cell models"

From Master Projects
Jump to: navigation, search
 
Line 3: Line 3:
 
|Contact person2=Niclas Nordhold
 
|Contact person2=Niclas Nordhold
 
|Contact person3=Douwe Molenaar
 
|Contact person3=Douwe Molenaar
|Master areas=Systems Biology
 
 
|Fulfilled=No
 
|Fulfilled=No
 
}}
 
}}
 +
 +
|free text=}}
 
When organisms change their growth rate because of changes in nutrient or stress conditions, they change the expression levels of enzymes participating in catabolism (generation of energy, lipids, nucleic acids, and amino acids), anabolism (protein and DNA synthesis out of amino acids and nucleic acids), and stress responses. A smart organism would in the presence of stress invest the minimally required amount of stress protein to maximise the protein amount available for growth processes. Such that this organism, in the presence of stress outgrows competitors. We have a lot of experience with whole cell models in lab, e.g. for E.coli and yeast, In this project, we would like to make such a model for B. subtilis (a microorganisms known to be very stress resistant) with stress responses to study optimal strategies for these organisms to deal with stress.
 
When organisms change their growth rate because of changes in nutrient or stress conditions, they change the expression levels of enzymes participating in catabolism (generation of energy, lipids, nucleic acids, and amino acids), anabolism (protein and DNA synthesis out of amino acids and nucleic acids), and stress responses. A smart organism would in the presence of stress invest the minimally required amount of stress protein to maximise the protein amount available for growth processes. Such that this organism, in the presence of stress outgrows competitors. We have a lot of experience with whole cell models in lab, e.g. for E.coli and yeast, In this project, we would like to make such a model for B. subtilis (a microorganisms known to be very stress resistant) with stress responses to study optimal strategies for these organisms to deal with stress.
  
 
== Type of project ==
 
== Type of project ==
 
* Modeling & Theory
 
* Modeling & Theory

Latest revision as of 09:50, 24 August 2016


About Simulation of optimal stress responses of microorganisms using whole-cell models


Description

|free text=}} When organisms change their growth rate because of changes in nutrient or stress conditions, they change the expression levels of enzymes participating in catabolism (generation of energy, lipids, nucleic acids, and amino acids), anabolism (protein and DNA synthesis out of amino acids and nucleic acids), and stress responses. A smart organism would in the presence of stress invest the minimally required amount of stress protein to maximise the protein amount available for growth processes. Such that this organism, in the presence of stress outgrows competitors. We have a lot of experience with whole cell models in lab, e.g. for E.coli and yeast, In this project, we would like to make such a model for B. subtilis (a microorganisms known to be very stress resistant) with stress responses to study optimal strategies for these organisms to deal with stress.

Type of project

  • Modeling & Theory